Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors from the central nervous procedure, conolidine modulates alternate molecular targets. A Science Advances review found that conolidine interacts With all the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://natural-bookmark.com/story20802370/an-unbiased-view-of-alternative-natural-pain-relief-to-replace-traditional-painkillers